Dr. Md. Lokman Hakim Choudhury

Research Areas:Diversity Oriented Synthesis (DOS) using multicomponent reactions (MCRs), the discovery and development of new synthetic methods with particular interest in heterocyclic chemistry and total synthesis of various biologically active natural products and structural analogues.

Research Group
:

Anoop Panday

Asim Jana

Richa Mishra

Danish Ali

Prabhas Bhowmick

Alok Mahata

Former Group Members:

Md. Nasim Khan (Ph.D, IIT Patna, 2016)

Suman Pal (Ph.D, IIT Patna, 2014)

Sheikh Karamthulla (Ph.D, IIT Patna, 2016)

Professional Experience:

• Lecturer in Chemistry, School of Technology, North-Eastern Hill University, Shillong (Jan 2007-Feb 2009)
• Royal Society Incoming Postdoctoral Fellow, The University of Manchester, UK

Teaching:

• CH-101: Chemistry for B.Tech 1st semester students)
• CH-201: Green Chemistry and Technology for B.Tech Students)
• CH-702: New Reagents for Organic Synthesis for PhD students)
• CH-704: Art in Organic Synthesis for PhD students)
• CH-203: Organic Chemistry for B.Tech CST)
• CH-206: Medicinal Chemistry and Drug Discovery for B.Tech CST)
• CH 423: Principles of Organic Chemistry (for M.Sc students)
• CH 430: Organic Chemistry Lab (for M.Sc students)
• CH 424: Reagents And Tools In Organic Chemistry (for M.Sc students)

Sponsored projects:

Publications:

• Synthesis of spirooxindoles fused with pyrazolo-tetrahydropyridinone and coumarin-dihydropyridine-pyrazole tetracycles by reaction medium dependent isatin-based multicomponent reactions. Richa Mishra, Asim Jana, Anoop Panday and Lokman H Choudhury, New Journal of Chemistry, 2019, 43, 2920-2932
• Synthesis of fused pyrroles containing 4-hydroxycoumarins by regioselective metal-free multicomponent reactions. Richa Mishra, Asim Jana, Anoop K. Panday and Lokman H. Choudhury, Organic & Biomolecular Chemistry, 2018, 16, 3289-3302.
• Lemon juice mediated multicomponent reactions for the synthesis of fused imidazoles, Argha Saha, Asim Jana and Lokman H. Choudhury, New Journal of Chemistry, 2018, 42, 17909-17922
• Synthesis of pyrimidine fused quinolines by ligand-free copper-catalyzed domino reactions. Anoop K. Panday, R. Mishra, A. Jana, T. Parvin and Lokman H. Choudhury, The Journal of Organic Chemistry 2018, 83, 3624-3632
• Recent advances of aminopyrimidines in multicomponent reactions, Ruchi Bharti, Pooja Kumari, Tasneem Parvin and Lokman H. Choudhury, Current Organic Chemistry, 2018, 22, 417-445. (Review article)
• Intracellular application and logic gate behavior of a ‘turn off-on-off’type probe for selective detection of Al 3+ and F− ions in pure aqueous medium. R. Dwivedi, D. P. Singh, B. S. Chauhan, S. Srikrishna, Anoop Kumar Panday, Lokman H Choudhury, V. P. Singh, Sensors and Actuators B: Chemical , 2018, 258, 881-894.
• Synthesis of thio and selenoethers of cyclic β‐hydroxy carbonyls and amino uracils: A metal‐free regioselective I2/DMSO mediated reaction. A. Jana, A.K. Panday, R. Mishra, T. Parvin, Lokman H. Choudhury, ChemistrySelect, 2017, 2, 9420-9424.
• Multicomponent reactions of arylglyoxal, 4‐hydroxycoumarin, and cyclic 1, 3‐C, N‐binucleophiles: binucleophile‐directed synthesis of fused five‐and six-membered N-heterocycles. R. Mishra, A.K. Panday, Lokman H. Choudhury, J Pal, R Subramanian, A Verma, European Journal of Organic Chemistry, 2017, 2789-2800.
• Synthesis of novel 5,6-disubstituted pyrrolo [2,3-d]pyrimidine-2,4-diones via one-pot three component reactions. Shaik Karamthulla, Asim Jana, and Lokman H. Choudhury, ACS Comb. Sci., 2017, 19,108-112.
• Molecular diversity from the three-component reaction of 2-hydroxy-1,4-naphthaquinone, aldehydes and 6-aminouracils: a reaction condition dependent MCR. R. Bharti, P. Kumari, Tasneem Parvin and Lokman H. Choudhury, RSC Adv., 2017, 7, 3928-3933.
• Catalyst-free microwave-assisted arylglyoxal-based multicomponent reactions for the synthesis of fused pyrans. Richa Mishra and Lokman H. Choudhury, RSC. Adv., 2016, 6, 24464-24469.
• Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium. Md. Nasim Khan, Shaik Karamthulla, Lokman H. Choudhury and Md. S. H. Faizi, RSC Adv., 2015, 5, 22168-22172.
• Microwave-assisted synthesis of novel 2, 3-disubstituted imidazo[1,2-a]pyridines via one-pot three component reactions. Shaik Karamthulla, Md. Nasim Khan and Lokman H. Choudhury, RSC Adv., 2015, 5, 19724-19733.
• Synthesis of pyranocoumarin fused spirooxindoles via Knoevenagel/Michael/cyclization sequence: a regioselective organocatalyzed multicomponent reaction. Suman Pal, Md. Nasim Khan, Shaik Karamthulla and Lokman H. Choudhury, Tetrahedron Lett., 2015, 56, 359–364.
• On-water" synthesis of novel trisubstituted 1, 3-thiazoles via microwave-assisted catalyst-free domino reactions. Shaik Karamthulla, Suman Pal, Md Nasim Khan, and Lokman H. Choudhury, RSC Adv., 2014, 4, 37889-37899.
• Multicomponent reactions (MCRs) for the facile access of coumarin fused dihydroquinolines and quinolines: Synthesis and photophysical studies. Md Nasim Khan, Suman Pal, Shaik Karamthulla and Lokman H. Choudhury, New J. Chem., 2014,38, 4722-4729.
• Synthesis of pentasubstituted pyrroles via catalyst free multicomponent reactions. Shaik Karamthulla, Suman Pal, Md Nasim Khan, and Lokman H. Choudhury, Synlett, 2014, 25, 1926. (Highlighted in Synfacts, 2014,10(10),1031.)
• L-proline catalyzed multicomponent reactions:facile access to 2H-benzo[g]pyrazolo[3,4-b]-quinoline-5,10(4H,11H)-dione derivatives. Shaik Karamthulla, Suman Pal, Tasneem Parvin and Lokman H. Choudhury, RSC Adv., 2014, 4, 15319–15324.
• Imidazole as organocatalyst for multicomponent reactions: Diversity oriented synthesis of functionalized hetero and carbocycles using in situ-generated benzylidenemalononitrile derivatives. Md Nasim Khan, Suman Pal, Shaik Karamthulla and Lokman H. Choudhury, RSC Adv., 2014, 4, 3732-3741.
• One pot four-component reaction for the efficient synthesis of spiro[indoline-3,4'-pyrano [2,3 c]pyrazole]-3'-carboxylate derivatives. Suman Pal, Md. Nasim Khan, Shaik Karamthulla, Sk Jahir Abbas and Lokman H. Choudhury, Tetrahedron Lett., 2013, 54, 5434-5440.
• KF/Al2O3 mediated multicomponent reactions for the efficient synthesis of highly substituted dihydropyridines. Suman Pal, Md. Nasim Khan and Lokman H. Choudhury, J. Heterocyclic Chem., 2014, 51, E156-E162.
• Synthesis of novel spiro[indoline-3,79-pyrrolo[1,2-c]imidazole]-6¢-carbonitrile derivatives in water using a regioselective sequential three component reaction. Shaik Karamthulla, Suman Pal, Md. Nasim Khan and Lokman H. Choudhury, RSC Adv., 2013, 3, 15576-15581.
• Molecular iodine catalyzed one-pot multicomponent reactions for the synthesis of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridin-6(7H)-ones. Suman Pal, Md. Nasim Khan, Shaik Karamthulla and Lokman H. Choudhury,  RSC Adv., 2013, 3, 15705-15711.
• PEG-mediated one-pot multicomponent reactions for the efficient synthesis of functionalized dihydropyridines and their functional group dependent DNA cleavage activity. Suman Pal, Vandana Singh, Prolay Das, Lokman H Choudhury. Bioorganic Chemistry, 2013, 48, 8-15.
• One-pot multicomponent reactions for the efficient synthesis of highly functionalized dihydropyridines. Suman Pal, Lokman H. Choudhury and Tasneem Parvin, Synth. Comm., 2013, 43, 986–992.
• A simple and efficient method for the facile access of highly functionalized pyridines and their fluorescence property studies. Md. Nasim Khan, Suman Pal, Tasneem Parvin and Lokman H. Choudhury, RSC Adv., 2012, 2, 12305–12314.
• Recent advances in the chemistry of imine-based multicomponent reactions (MCRs). Lokman H. Choudhury and Tasneem Parvin, Tetrahedron , 2011, 67, 8213-8228.(Review article)
• VCl3 catalyzed imine-based multicomponent reactions for the facile access of functionalized tetrahydropyridines and β-amino carbonyls. Suman Pal, Lokman H. Choudhury and Tasneem Parvin, Mol. Divers., 2012, 16, 129-143.
• A stereoselective cyclisation cascade mediated by SmI2–H2O: synthetic studies towards stolonidiol. Thomas M. Baker, Lisa A. Sloan, Lokman H. Choudhury, Masahito Murai, David J. Procter, Tetrahedron: Asymmetry, 2010, 21, 1246-1261.
• Recent advances in the application of bromodimethylsulfonium bromide (BDMS) in organic synthesis. Lokman H. Choudhury, Tasneem Parvin and Abu. T. Khan, Tetrahedron , 2009, 65, 9513-9526.(Review article)
• A simple and convenient one-pot synthesis of benzimidazole derivatives using cobalt(II) chloride hexahydrate as catalyst. Abu T. Khan, Tasneem Parvin, and Lokman H. Choudhury, Synth. comm. 2009, 39, 2339-2346.
• Effects of substituents in the β-position of 1, 3-dicarbonyl compounds in Bromodimethylsulfonium bromide catalyzed multicomponent reactions: A facile access to functionalized piperidines. Abu T. Khan, Tasneem Parvin, and Lokman H. Choudhury, J. Org. Chem., 2008, 73, 8398–8402.
• Bromodimethylsulfonium bromide (BDMS) catalyzed three-component Mannich-type reaction. Abu T. Khan, Tasneem Parvin, and Lokman H. Choudhury, Eur. J. Org. Chem., 2008, 834-839.
• Bromodimethylsulfonium bromide mediated aza-Micheal addition of amines to electron deficient alkenes. Abu T. Khan, Tasneem Parvin, Sarifuddin Gazi and Lokman H. Choudhury, Tetrahedron Lett., 2007, 48, 3805-3808.
• Iron (III) chloride catalyzed convenient one-pot synthesis of β-acetamido carbonyl compounds. Abu T. Khan, Tasneem Parvin and Lokman H. Choudhury, Tetrahedron, 2007, 63, 5593-5601.
• A simple and convenient synthetic protocol for oxidation of alkyl arenes into ketones using aqueous hydrogen bromide/hydrogen peroxide. Abu T. Khan, Tasneem Parvin, Lokman H. Choudhury and Subrata Ghosh, Tetrahedron Lett., 2007, 48, 2271-2274.
• CeCl3.7H2O: An efficient and reusable catalyst for the preparation of β-acetamido carbonyl compounds by multi-component reactions (MCRs). Abu T. Khan, Lokman H. Choudhury, Tasneem Parvin and Md. Asif Ali, Tetrahedron Lett., 2006, 47, 8137-8141.
• A mild and highly regioselective method for α-bromination of β-keto esters and 1,3-diketones using bromodimethylsulfonium bromide (BDMS). Abu T. Khan, Md. Asif Ali, Papori Goswami and Lokman H. Choudhury, J.Org. Chem., 2006, 71, 8961-8963.
• Silica supported perchloric acid(HClO4-SiO2): A versatile catalyst for the tetrahydropyranylation, thioacetalization and oxathioacetalization. Abu T. Khan, Tasneem Parvin and Lokman H. Choudhury, Synthesis, 2006, 2497-2502.
• Bromodimethylsulfonium bromide: A versatile reagent in organic synthesis. Md. Lokman H. Choudhury, Synlett, Spotlight 2006, 1619.
• Silica supported perchloric acid (HClO4-SiO2): A highly efficient and reusable catalyst for geminal diacylation of aldehydes under solvent-free conditions. Abu T. Khan, Lokman H. Choudhury and Subrata Ghosh, Journal of Molecular Catalysis A: Chemical, 2006, 255, 230.
• A mild and environmentally acceptable synthetic protocol for chemoselective α-bromination of β-keto ester and 1,3-diketones. Abu T. Khan, Papori Goswami, and Lokman H. Choudhury, Tetrahedron Lett.,2006, 47, 2751-2754.
• Perchloric acid impregnated on silica gel (HClO4- SiO2): A versatile catalyst for Michael addition of thiols to the electron deficient alkenes. Abu T. Khan, Subrata Ghosh and Lokman H. Choudhury, Eur. J. Org. Chem., 2006, 2226-223.
• A Highly efficient synthetic protocol for tetrahydropyranylation/depyranylation of alcohols and phenols. Abu T. Khan, Subrata Ghosh and Lokman H. Choudhury, Eur. J. Org. Chem., 2005, 4891-4896.
• Acetonyltriphenylphosphonium bromide (ATPB): A versatile reagent for the acylation of alcohols, phenols, thiols, amines and for 1, 1-diacylation of aldehydes under solvent-free conditions. Abu T. Khan, Lokman H. Choudhury and Subrata Ghosh, Eur. J. Org. Chem., 2005, 2782-2787.
• A catalytic amount of nickel (II) chloride hexahydrate and 1, 2- ethanedithiol is a good combination for the cleavage of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers. Abu T. Khan, Samimul Islam, Lokman H. Choudhury and Subrata Ghosh, Tetrahedron Lett., 2004, 45, 9617-962.
• Cupric sulfate pentahydrate (CuSO4.5H2O): A mild and efficient catalyst for tetrahydropyranylation /depyranylation of alcohols and phenols. Abu T. Khan, Lokman H. Choudhury and Subrata Ghosh,Tetrahedron Lett., 2004, 45, 7891-7894.
• A simple and useful synthetic protocol for selective deprotection of tert -butyldimethylsilyl (TBS) ethers.Abu T. Khan, Subrata Ghosh and Lokman H. Choudhury, Eur. J. Org. Chem., 2004, 2198-2204.

Conferences Attended:

• 13th Tetrahedron Symposium Asia Edition, Taipei, Taiwan - November 27-30, 2012